Restylane Heritage

Safety and reliability

Restylane's record of efficacy and safety has resulted in a range of products that you and your healthcare practitioner can trust.

  • World’s first stabilized and FDA-approved non-animal HA filler
  • Over 20 years of clinical legacy
  • Over 30 million treatments worldwide
  • Over 3000 patients followed in clinical trials
  • Over 150 scientific publications and 40 randomized controlled trials
Over 30 million Restylane treatments
Over 30 million Restylane treatments
Over 220 scientific publications and randomized controlled clinical trials in aesthetics
20 years of clinical legacy
20 years of clinical legacy

Today, Restylane has the broadest range of HA-based products backed up with decades of clinical experience demonstrating safety and long-lasting results. Whether you are looking to smooth away wrinkles, add definition to facial features or simply improve the condition of your skin, there is a Restylane product tailored to your needs.

Speak to a healthcare practitioner to find out more.


Healthcare professionals and patients across the globe use Restylane

Learn more on the reasons why healthcare practitioners are confident using Restylane.

How Restylane came to be

In the late 1980s, Swedish scientist and entrepreneur Bengt Ågerup had a vision to bring his scientific work on HA out of the lab and into the real world. Ågerup and his fellow scientists wanted to find a way to restore skin moisture and structure by creating a product that could deliver naturally occurring HA into the skin. It had to be safe – closely resembling natural HA so that it would not be detected by the body as a foreign substance and cause an immune reaction – and offer long-lasting results.

The product was Restylane, the world’s first stabilized non-animal HA filler.

And the innovation didn’t stop there. Since Restylane was launched in 1996, new ranges of products have been developed to suit patients’ individual needs. Diverse textures offer different levels of lift or volume, and some formulations are focusing on the quality of the skin.


20 years of proof in real life

Louise, 65 years old, from Sweden, was one of the very first patients to be treated with Restylane in 1996. Louise has been continuously treated with Restylane over the past 20 years. She will continue to use the product to help her keep her natural look as she ages gracefully.  

See what patients think of Restylane treatments